Kaley Cuoco is making it clear—she’s far from done with Hollywood. In fact, she’s busier than ever. From reuniting with her former Big Bang Theory co-star Johnny Galecki in a fun, nostalgic commercial, to starring in the upcoming mystery drama Vanished, Cuoco is proving she’s still a top-tier talent.

She’s also returning as the voice of Harley Quinn in season 5 of the hit animated series, where her character heads to Metropolis for a wild new chapter alongside Poison Ivy. And if that’s not enough, Kaley is stepping into a brand-new HBO comedy, Kansas City Star, playing a washed-up actress returning to her hometown to revive her career.

Fans have loved Kaley since her days as Penny, but now she’s proving that her range—and her ambition—go far beyond sitcoms. Whether it’s comedy, animation, or drama, Kaley Cuoco is a powerhouse who isn’t hitting the brakes anytime soon.